Summary
Chemical Biology is an interdisciplinary field using chemical principles and techniques to analyse and manipulate biological systems. It relies on small-molecule chemicals to gain an in-depth understanding of biology, and provides new tools and products ranging from basic research to therapeutics.
Content
This class revolves around the following central question: “How can we use chemical tools to probe and manipulate biology on all levels of the central dogma of molecular biology (i.e. DNA, RNA and protein)?”
The following topics are covered (non-comprehensive overview):
o sequencing and synthesis of DNA, RNA and proteins
o gene and genome editing, mutagenesis
o probing and manipulation of nucleic acids and proteins
o enzymes (kinetics, inhibition and modulation)
o biosensors
o metabolic regulation and signaling
- Professor: Markus Jeschek
